GSK3beta Genetic Network

 

Using a discovery and replication sample we replicated multiple two-SNP interactions with hippocampal volume in recurrent major depressive disorder (MDD). These replicable results involved variants in genes with functions relevant to depression, including endoplasmic reticulum stress, calcium regulation, and histone modifications. Our findings are relevant to cognitive impairments in depression and we speculate that micro RNA 124 and peroxisome proliferator-activated receptor-gamma play important roles.